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Cambridge Immunology Network

 

Research

Clinical evaluation of newer immunotherapeutics in vasculitis, lupus and immune-mediated renal disease. Co-ordination of international clinical research vasculitis network (EUVAS) and multi-centre randomised controlled trials. Development of clinical trial methodology, management guidelines and implementation of best clinical practice. Support of genetic, gene expression and biomarker studies

Publications

Key publications: 

1: Bashford-Rogers RJM, Bergamaschi L, McKinney EF, Pombal DC, Mescia F, Lee JC, Thomas DC, Flint SM, Kellam P, Jayne DRW, Lyons PA, Smith KGC.

Analysis of the B cell receptor repertoire in six immune-mediated diseases.

Nature. 2019 Sep 25.

doi: 10.1038/s41586-019-1595-3. [Epub ahead of print] PubMed PMID: 31554970.

 

 

2: Cassia MA, Alberici F, Jones RB, Smith RM, Casazza G, Urban ML, Emmi G, Moroni G, Sinico RA, Messa P, Hall F, Vaglio A, Gallieni M, Jayne DR.

Rituximab as Maintenance Treatment for Systemic Lupus Erythematosus: A Multicenter Observational Study of 147 Patients.

 Arthritis Rheumatol. 2019 Oct;71(10):1670-1680.

doi: 10.1002/art.40932. Epub 2019 Aug 30. PubMed PMID: 31102498.

 

 

3: Lee KS, Kronbichler A, Pereira Vasconcelos DF, Pereira da Silva FR, Ko Y, Oh YS, Eisenhut M, Merkel PA, Jayne D, Amos CI, Siminovitch KA, Rahmattulla C, Lee KH, Shin JI.

Genetic Variants in Antineutrophil Cytoplasmic Antibody-Associated Vasculitis: A Bayesian Approach and Systematic Review.

 J Clin Med. 2019 Feb 21;8(2). pii: E266.

 doi: 10.3390/jcm8020266. PubMed PMID: 30795559; PubMed Central PMCID: PMC6406345.

 

 

4: Pepper RJ, McAdoo SP, Moran SM, Kelly D, Scott J, Hamour S, Burns A, Griffith  M, Galliford J, Levy JB, Cairns TD, Gopaluni S, Jones RB, Jayne D, Little MA, Pusey CD, Salama AD.

 A novel glucocorticoid-free maintenance regimen for anti-neutrophil cytoplasm antibody-associated vasculitis.

Rheumatology (Oxford).  2019 Feb 1;58(2):373.

doi: 10.1093/rheumatology/kez001. PubMed PMID: 30690635.

 

 

5: Jayne D, Blockmans D, Luqmani R, Moiseev S, Ji B, Green Y, Hall L, Roth D, Henderson RB, Merkel PA; BREVAS Study Collaborators.

Efficacy and Safety of Belimumab and Azathioprine for Maintenance of Remission in Antineutrophil

Cytoplasmic Antibody-Associated Vasculitis: A Randomized Controlled Study.

Arthritis Rheumatol. 2019 Jun;71(6):952-963.

doi: 10.1002/art.40802. Epub 2019 Apr 16. PubMed PMID: 30666823; PubMed Central PMCID: PMC6593987.

 

 

6: Jones RB, Hiemstra TF, Ballarin J, Blockmans DE, Brogan P, Bruchfeld A, Cid MC, Dahlsveen K, de Zoysa J, Espigol-Frigolé G, Lanyon P, Peh CA, Tesar V, Vaglio A, Walsh M, Walsh D, Walters G, Harper L, Jayne D; European Vasculitis StudyGroup (EUVAS).

Mycophenolate mofetil versus cyclophosphamide for remission induction in ANCA-associated vasculitis: a randomised, non-inferiority trial.

Ann Rheum Dis. 2019 Mar;78(3):399-405.

doi: 10.1136/annrheumdis-2018-214245. Epub 2019 Jan 5. PubMed PMID: 30612116.

 

 

7: Gopaluni S, Flossmann O, Little MA, O'Hara P, Bekker P, Jayne D; European Vasculitis Society. Effect of Disease Activity at Three and Six Months After Diagnosis on Long-Term Outcomes in Antineutrophil Cytoplasmic Antibody-Associated Vasculitis.

Arthritis Rheumatol. 2019 May;71(5):784-791.

doi: 10.1002/art.40776. Epub 2019 Mar 28. PubMed PMID: 30418705.

 

 

8: Kronbichler A, Blane B, Holmes MA, Wagner J, Parkhill J, Peacock SJ, Jayne DRW, Harrison EM. Nasal carriage of Staphylococcus pseudintermedius in patients with granulomatosis with polyangiitis. Rheumatology (Oxford). 2019 Mar 1;58(3):548-550.

doi: 10.1093/rheumatology/key317. PubMed PMID: 30412252; PubMed Central PMCID: PMC6381761.

 

 

9: McClure M, Gopaluni S, Jayne D, Jones R.

B cell therapy in ANCA-associated vasculitis: current and emerging treatment options.

Nat Rev Rheumatol. 2018 Oct;14(10):580-591.

doi: 10.1038/s41584-018-0065-x. Epub 2018 Aug 14. Review.

Erratum in: Nat Rev Rheumatol. 2018 Dec;14(12):741. PubMed PMID: 30108367.

 

 

10: Karadag O, Erden A, Bilginer Y, Gopaluni S, Sari A, Armagan B, Ertenli I, Ozen S, Jayne D.

A retrospective study comparing the phenotype and outcomes of patients with polyarteritis nodosa between UK and Turkish cohorts.

Rheumatol Int. 2018 Oct;38(10):1833-1840.

 doi: 10.1007/s00296-018-4122-1. Epub 2018 Aug 11. PubMed PMID: 30099592.

 

 

11: McAdoo SP, Medjeral-Thomas N, Gopaluni S, Tanna A, Mansfield N, Galliford J, Griffith M, Levy J, Cairns TD, Jayne D, Salama AD, Pusey CD.

 Long-term follow-up of a combined rituximab and cyclophosphamide regimen in renal anti-neutrophil cytoplasm antibody-associated vasculitis

Nephrol Dial Transplant. 2019 Jan1;34(1):63-73.

doi: 10.1093/ndt/gfx378.

Erratum in: Nephrol Dial Transplant. 2018May 1;33(5):899. PubMed PMID: 29462348; PubMed Central PMCID: PMC6322443.

 

 

12: McCarthy EM, Sutton E, Nesbit S, White J, Parker B, Jayne D, Griffiths B, Isenberg DA, Rahman A, Gordon C, D'Cruz DP, Rhodes B, Lanyon P, Vital EM, Yee CS, Edwards CJ, Teh LS, Akil M, McHugh NJ, Zoma A, Bruce IN British Isles Lupus Assessment Group Biologics Register.

 Short-term efficacy and safety of rituximab therapy in refractory systemic lupus erythematosus: results from the British Isles Lupus Assessment Group Biologics Register.

Rheumatology (Oxford). 2018 Mar 1;57(3):470-479.

doi: 10.1093/rheumatology/kex395. PubMed PMID: 29216396; PubMed Central PMCID: PMC5850287.

 

 

13: Bossuyt X, Cohen Tervaert JW, Arimura Y, Blockmans D, Flores-Suárez LF, Guillevin L, Hellmich B, Jayne D, Jennette JC, Kallenberg CGM, Moiseev S, Novikov P, Radice A, Savige JA, Sinico RA, Specks U, van Paassen P, Zhao MH, Rasmussen N, Damoiseaux J, Csernok E.

Position paper: Revised 2017 international consensus on testing of ANCAs in granulomatosis with polyangiitis and microscopic polyangiitis.

Nat Rev Rheumatol. 2017 Nov;13(11):683-692.

 doi:10.1038/nrrheum.2017.140. Epub 2017 Sep 14. Review. PubMed PMID: 28905856.

 

 

14: Mohammad AJ, Segelmark M, Smith R, Englund M, Nilsson JÅ, Westman K, Merkel PA, Jayne DRW.

Severe Infection in Antineutrophil Cytoplasmic Antibody-associated Vasculitis.

 J Rheumatol. 2017 Oct;44(10):1468-1475.

doi: 10.3899/jrheum.160909.

Epub 2017 Aug 1. PubMed PMID: 28765251.

 

 

15: Karras A, Pagnoux C, Haubitz M, Groot K, Puechal X, Tervaert JWC, Segelmark M, Guillevin L, Jayne D; European Vasculitis Society.

Randomised controlled trial of prolonged treatment in the remission phase of ANCA-associated vasculitis.

Ann Rheum Dis. 2017 Oct;76(10):1662-1668.

doi: 10.1136/annrheumdis-2017-211123. Epub 2017 May 25. PubMed PMID: 28546260.

 

 

16: Wechsler ME, Akuthota P, Jayne D, Khoury P, Klion A, Langford CA, Merkel PA,  Moosig F, Specks U, Cid MC, Luqmani R, Brown J, Mallett S, Philipson R, Yancey SW, Steinfeld J, Weller PF, Gleich GJ; EGPA Mepolizumab Study Team.

Mepolizumab or Placebo for Eosinophilic Granulomatosis with Polyangiitis.

N Engl J Med. 2017 May 18;376(20):1921-1932.

doi: 10.1056/NEJMoa1702079. PubMed PMID: 28514601; PubMed Central PMCID: PMC5548295.

 

 

17: Jayne DRW, Bruchfeld AN, Harper L, Schaier M, Venning MC, Hamilton P, Burst V, Grundmann F, Jadoul M, Szombati I, Tesař V, Segelmark M, Potarca A, Schall TJ, Bekker P; CLEAR Study Group. Randomized Trial of C5a Receptor Inhibitor Avacopan in ANCA-Associated Vasculitis.

J Am Soc Nephrol. 2017 Sep;28(9):2756-2767.

doi: 10.1681/ASN.2016111179. Epub 2017 Apr 11. PubMed PMID: 28400446; PubMed Central

PMCID: PMC5576933.

 

 

18: Gopaluni S, Smith RM, Lewin M, McAlear CA, Mynard K, Jones RB, Specks U, Merkel PA, Jayne DR; RITAZAREM Investigators.

 Rituximab versus azathioprine as therapy for maintenance of remission for anti-neutrophil cytoplasm antibody-associated vasculitis (RITAZAREM): study protocol for a randomized

controlled trial.

Trials. 2017 Mar 7;18(1):112.

doi: 10.1186/s13063-017-1857-z.

PubMed PMID: 28270229; PubMed Central PMCID: PMC5341185.

 

 

19: Yates M, Watts RA, Bajema IM, Cid MC, Crestani B, Hauser T, Hellmich B, Holle JU, Laudien M, Little MA, Luqmani RA, Mahr A, Merkel PA, Mills J, Mooney J,Segelmark M, Tesar V, Westman K, Vaglio A, Yalçındağ N, Jayne DR, Mukhtyar C.

EULAR/ERA-EDTA recommendations for the management of ANCA-associated vasculitis.

Ann Rheum Dis. 2016 Sep;75(9):1583-94.

doi: 10.1136/annrheumdis-2016-209133. Epub 2016 Jun 23. Erratum in: Ann Rheum Dis. 2017 Aug;76(8):1480. PubMed PMID: 27338776.

 

 

20: Kronbichler A, Brezina B, Quintana LF, Jayne DR.

Efficacy of plasma exchange and immunoadsorption in systemic lupus erythematosus and antiphospholipidsyndrome: A systematic review.

 Autoimmun Rev. 2016 Jan;15(1):38-49.

 doi:10.1016/j.autrev.2015.08.010. Epub 2015 Aug 28. Review. PubMed PMID: 26318215.

 

 

21: Mohammad AJ, Smith RM, Chow YW, Chaudhry AN, Jayne DR.

Alemtuzumab as Remission Induction Therapy in Behçet Disease: A 20-year Experience.

J Rheumatol. 2015 Oct;42(10):1906-13.

doi: 10.3899/jrheum.141344. Epub 2015 Aug 15. PubMed PMID: 26276966.

 

 

22: McKinney EF, Lee JC, Jayne DR, Lyons PA, Smith KG.

T-cell exhaustion, co-stimulation and clinical outcome in autoimmunity and infection.

Nature. 2015 Jul 30;523(7562):612-6.

doi: 10.1038/nature14468. Epub 2015 Jun 29. PubMed PMID: 26123020; PubMed Central PMCID: PMC4623162.

 

 

23: Jones RB, Walsh M, Chaudhry AN, Smith KG, Jayne DR.

Randomized trial of enteric-coated mycophenolate sodium versus mycophenolate mofetil in multi-system autoimmune disease.

 Clin Kidney J. 2014 Dec;7(6):562-8.

doi: 10.1093/ckj/sfu096. Epub 2014 Sep 16. PubMed PMID: 25859373; PubMed Central PMCID: PMC4389135.

 

 

24: Jones RB, Furuta S, Tervaert JW, Hauser T, Luqmani R, Morgan MD, Peh CA, Savage CO, Segelmark M, Tesar V, van Paassen P, Walsh M, Westman K, Jayne DR; European Vasculitis Society (EUVAS).

Rituximab versus cyclophosphamide in ANCA-associated renal vasculitis: 2-year results of a randomised trial.

Ann Rheum Dis. 2015 Jun;74(6):1178-82.

doi: 10.1136/annrheumdis-2014-206404. Epub 2015 Mar 4. PubMed PMID: 25739829.

 

 

25: Jayne D.

Extending the indications for rituximab in ANCA-associated vasculitis.

N Engl J Med. 2014 Nov 6;371(19):1839-40.

doi: 10.1056/NEJMe1410394. PubMed PMID: 25372093.

 

 

26: Robson J, Doll H, Suppiah R, Flossmann O, Harper L, Höglund P, Jayne D, Mahr A, Westman K, Luqmani R.

Glucocorticoid treatment and damage in the anti-neutrophil cytoplasm antibody-associated vasculitides: long-term data from the European Vasculitis Study Group trials.

Rheumatology (Oxford). 2015 Mar;54(3):471-81.

doi: 10.1093/rheumatology/keu366. Epub 2014 Sep 8. PubMed PMID: 25205825.

 

 

27: Wallin EF, Jolly EC, Suchánek O, Bradley JA, Espéli M, Jayne DR, Linterman MA, Smith KG.

Human T follicular helper and T follicular regulatory cell maintenance is independent of germinal centers. 

Blood. 2014 Sep 15. pii: blood-2014-07-585976.

 

 

28: Walsh M, Faurschou M, Berden A, Flossmann O, Bajema I, Hoglund P, Smith R, Szpirt W, Westman K, Pusey CD, Jayne DR; European Vasculitis Study Group. 

Long-term follow-up of cyclophosphamide compared with azathioprine for initial maintenance therapy in ANCA-associated vasculitis. 

Clin J Am Soc Nephrol. 2014 Sep 5;9(9):1571-6. d

 

29: Marco H, Smith RM, Jones RB, Guerry MJ, Catapano F, Burns S, Chaudhry AN, Smith KG, Jayne DR. 

The effect of rituximab therapy on immunoglobulin levels in patients with multisystem autoimmune disease. 

BMC Musculoskelet Disord. 2014;15:178.

 

 

30: Furuta S, Chow YW, Chaudhry AN, Jayne D.

Switching of anti-TNF-α agents in Behçet's disease. 

Clin Exp Rheumatol. 2012 Sep 25.

 

 

31: Lyons PA, Rayner TF, Trivedi S, Holle JU, Watts RA, Jayne DR, Baslund B, Brenchley P, Bruchfeld A, Chaudhry AN, Cohen Tervaert JW, Deloukas P, Feighery C, Gross WL, Guillevin L, Gunnarsson I, Harper L, Hrušková Z, Little MA, Martorana D, Neumann T, Ohlsson S, Padmanabhan S, Pusey CD, Salama AD, Sanders JS, Savage CO, Segelmark M, Stegeman CA, Tesař V, Vaglio A, Wieczorek S, Wilde B, Zwerina J, Rees AJ, Clayton DG, Smith KG.

Genetically distinct subsets within ANCA-associated vasculitis 

N Engl J Med. 2012 Jul 19;367(3):214-23

 

 

32: Smith RM, Jones RB, Guerry MJ, Laurino S, Catapano F, Chaudhry A, Smith KG, Jayne DR.

 Rituximab for remission maintenance in relapsing ANCA-associated vasculitis. 

Arthritis Rheum. 2012 Jun 21.

 

 

33: Smith RM, Jones RB, Jayne DR.

Progress in treatment of ANCA-associated vasculitis.

Arthritis Res Ther. 2012 Apr 30;14(2):210.

 

 

34: Guerry MJ, Brogan P, Bruce IN, D'Cruz DP, Harper L, Luqmani R, Pusey CD, Salama AD, Scott DG, Savage CO, Watts RA, Jayne DR.

Recommendations for the use of rituximab in anti-neutrophil cytoplasm antibody-associated vasculitis. 

Rheumatology (Oxford). 2012 Apr;51(4):634-43.

 

 

35: Jones RB, Tervaert JW, Hauser T, Luqmani R, Morgan MD, Peh CA, Savage CO, Segelmark M, Tesar V, van Paassen P, Walsh D, Walsh M, Westman K, Jayne DR; European Vasculitis Study Group.  

Rituximab versus cyclophosphamide in ANCA-associated renal vasculitis.

N Engl J Med. 2010;363:211–220.

Dr David  Jayne
Takes PhD students
Not available for consultancy

Affiliations

Departments and institutes: 
Person keywords: 
clinical trials
B cells
monoclonal antibodies
immunotherapy
human studies
clinical immunology
antibody engineering