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Cambridge Immunology Network



Investigation of the impact of gut microbiota on the intestinal epigenome (focused on DNA methylation) during health and inflammatory bowel diseases (Crohn's disease and Ulcerative Colitis). 


Key publications: 

Mak TN, Sfanos KS, Brüggemann H. Draft genome sequences of two strains of Propionibacterium acnes isolated from radical prostatectomy specimens. Genome Announcements (2013) 1(6). pii: e01071-13.
Mak TN, Schmid M, Brzuszkiewicz E, Zeng G, Meyer R, Sfanos KS, Brinkmann V, Meyer TF, Brüggemann H. Comparative genomics reveals distinct host-interacting traits of three major human-associated propionibacteria. BMC Genomics (2013) 14(1): 640
Fischer N, Mak TN, Shinohara DB, Sfanos KS, Meyer TF, Brüggemann H. Deciphering the intracellular fate of Propionibacterium acnes in macrophages. BioMed Research International (2013) doi: 10.1155/2013/603046
Shinohara DB, Vaghasia A, Yu S, Mak TN, Brüggemann H, Nelson WG, De Marzo AM, Yegnasubramanian S, Sfanos KS. A mouse model of chronic prostatic inflammation using a human prostate cancer-derived isolate of Propionibacterium acnes. The Prostate (2013) 73(9):1007-1015
Mak TN*, Yu S*, De Marzo AM, Brüggemann H, Sfanos KS. Multilocus Sequence Typing (MLST) analysis of Propionibacterium acnes isolates from radical prostatectomy specimens. The Prostate (2012) 73(7): 770-777 *equal contribution

Mak TN, Fischer N, Laube B, Brinkmann V, Metruccio ME, Sfanos KS, Mollenkopf H, Meyer TF, Brüggemann H. Propionibacterium acnes host cell tropism contributes to vimentin-mediated invasion and induction of inflammation. Cellular Microbiology (2012) 14(11):1720-33

Dr Tim  Mak
Not available for consultancy


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