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Dr Tim Mak

Research Interests

Investigation of the impact of gut microbiota on the intestinal epigenome (focused on DNA methylation) during health and inflammatory bowel diseases (Crohn's disease and Ulcerative Colitis). 


  • Ulcerative Colitis
  • Crohn's disease

Key Publications

Mak TN, Sfanos KS, Brüggemann H. Draft genome sequences of two strains of Propionibacterium acnes isolated from radical prostatectomy specimens. Genome Announcements (2013) 1(6). pii: e01071-13.
Mak TN, Schmid M, Brzuszkiewicz E, Zeng G, Meyer R, Sfanos KS, Brinkmann V, Meyer TF, Brüggemann H. Comparative genomics reveals distinct host-interacting traits of three major human-associated propionibacteria. BMC Genomics (2013) 14(1): 640
Fischer N, Mak TN, Shinohara DB, Sfanos KS, Meyer TF, Brüggemann H. Deciphering the intracellular fate of Propionibacterium acnes in macrophages. BioMed Research International (2013) doi: 10.1155/2013/603046
Shinohara DB, Vaghasia A, Yu S, Mak TN, Brüggemann H, Nelson WG, De Marzo AM, Yegnasubramanian S, Sfanos KS. A mouse model of chronic prostatic inflammation using a human prostate cancer-derived isolate of Propionibacterium acnes. The Prostate (2013) 73(9):1007-1015
Mak TN*, Yu S*, De Marzo AM, Brüggemann H, Sfanos KS. Multilocus Sequence Typing (MLST) analysis of Propionibacterium acnes isolates from radical prostatectomy specimens. The Prostate (2012) 73(7): 770-777 *equal contribution

Mak TN, Fischer N, Laube B, Brinkmann V, Metruccio ME, Sfanos KS, Mollenkopf H, Meyer TF, Brüggemann H. Propionibacterium acnes host cell tropism contributes to vimentin-mediated invasion and induction of inflammation. Cellular Microbiology (2012) 14(11):1720-33