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Dr Matthias Zilbauer

Research Interests

Our research theme is focused on epigenetics of the intestinal immune system in health and disease particularly inflammatory bowel disease (IBD). Specifically, we are currently exploring the impact of epigenetic mechanisms such as DNA methylation and histone modifications on regulating gene expression in purified cell subsets such as the intestinal epithelium as well as peripheral blood mononuclear cells (PBMCs).


DNA methylation ; mucosal immunology ; intestinal innate immunity


  • inflammatory bowel disease
  • pediatric medicine

Key Publications

Atherton R, Ross A, Jessop F, Williams R, Heuschkel R, Zilbauer M. Coeliac Disease in Children with Type 1 Diabetes - Are Current Guidelines Proving Difficult to Implement in Practice? J Pediatr Gastroenterol Nutr. 2014 Jul 23. [Epub ahead of print]

Ross A, Shelley H, Novell K, Ingham E, Callan J, Heuschkel R, Morris MA, Zilbauer M. Assessing quality outcome measures in children with coeliac disease--experience from two UK centres. Nutrients. 2013 Nov 19;5(11):4605-13. 

Zilbauer M., Rayner T.F., Clark C., Coffey A.J., Joyce C.J., Palta P., Palotie A., Lyons P.A.Smith K.G.C. Genome-wide methylation analyses of primary human leukocyte subsets identifies functionally important cell-type specific hypomethylated regions Blood 24 Oct 2013

Shahnaz A, Maguire G, Parker R, Heuschkel RB, Zilbauer M. Tissue transglutaminase antibody levels predict IgA deficiency. Arch Dis Child. 2013 Aug

Jenke AC, Zilbauer M, Postberg J, Wirth S. Human beta-defensin 2 expression in ELBW infants with severe necrotizing enterocolitis. Pediatr Res, 2012. 72(5): p. 513-20.

Jenke, A.C. and Zilbauer M., Epigenetics in inflammatory bowel disease. Curr Opin Gastroenterol, 2012. 28(6): p. 577-84.

Zilbauer M, Jenke A, Wenzel G, Goedde D, Postberg J, Phillips AD, Lucas M, Noble-Jamieson G, Torrente F, Salvestrini C, Heuschkel R, Wirth S.Intestinal alpha-defensin expression in pediatric inflammatory bowel disease. Inflamm Bowel Dis, 2011. 17(10): p. 2076-86.

Schenk R, Jenke A, Zilbauer M, Wirth S, Postberg J. H3.5 is a novel hominid-specific histone H3 variant that is specifically expressed in the seminiferous tubules of human testes. Chromosoma, 2011. 120(3): p. 275-85.

Zilbauer, M, Jenke A, Wenzel G, Postberg J, Heusch A, Phillips AD, Noble-Jamieson G, Torrente F, Salvestrini C, Heuschkel R, Wirth S. Expression of human beta-defensins in children with chronic inflammatory bowel disease. PLoS One, 2010. 5(10): p. e15389.

Edwards LA, Nistala K, Mills DC, Stephenson HN, Zilbauer M, Wren BW, Dorrell N, Lindley KJ, Wedderburn LR, Bajaj-Elliott M. Delineation of the innate and adaptive T-cell immune outcome in the human host in response to Campylobacter jejuni infection. PLoS One, 2010. 5(11): p. e15398.