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Cambridge Immunology Network



We are interested in cell autonomous innate immunity, i.e. in the ability of individual cells to defend themselves against infection.

Cytosolic defence against bacterial invasion
The cytosol is rich in nutrients but very few bacteria can colonize it. We wish to understand how cells deploy the ubiquitin system and autophagy to defend their cytosol.

Regulation of NF-kB and IRF signalling
The defence against pathogens requires profound changes in gene expression, which are coordinated by latent transcription factors of the NF-kB and IRF families. We aim to understand how infection activates NF-kB and IRF signalling.

Somatic cell genetics
The genetic analysis of somatic cell lines holds significant potential to our understanding of signal transduction (and other cell autonomous traits). Through homologous recombination and chemical mutagenesis we have obtained a large collection of gene deficient human and murine cells, with which we address problems of cell autonomous innate immunity.


Key publications: 
Dr Felix  Randow
Takes PhD students
Available for consultancy


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