skip to primary navigationskip to content
 

Dr Shaun Flint

Dr Shaun Flint

Translational Medicine and Therapeutics PhD Student

Autoimmunity

Vasculitis

Nephrology

Genomics


Research Interests

Supervisor: Professor Ken Smith

My current research aims to identify clinically useful biomarkers in Takayasu’s Arteritis (TA) and Behçet’s disease, and examine geographic differences in Systemic Lupus Erythematosus (SLE) using as a starting point a prospectively collected dataset of gene expression data derived from the separated leukocyte subsets of patients presenting with active SLE and vasculitis.

Keywords

autoimmunity ; cytotoxic T cells (CTL) ; microarrays ; T cells ; immunophenotyping ; biomarkers ; transcriptome ; bioinformatics ; FACS ; translational immunology ; diagnostic tests

Topics

  • Takayasu's arteritis
  • systemic lupus erythematosus
  • Behcet's disease
  • Wegener's granulomatosis

Key Publications

Richard AC, Lyons PA, Peters JE, Biasci D, Flint SM, Lee JC, McKinney EF, Siegel RM, Smith KG.
Comparison of gene expression microarray data with count-based RNA measurements informs microarray interpretation. BMC Genomics. 2014 Aug 4;15(1):649. 

Ferreira RC, Guo H, Coulson RM, Smyth DJ, Pekalski ML, Burren OS, Cutler AJ, Doecke JD, Flint S, McKinney EF, Lyons PA, Smith KG, Achenbach P, Beyerlein A, Dunger DB, Wicker LS, Todd JA, Bonifacio E, Wallace C, Ziegler AG. A type I interferon transcriptional signature precedes autoimmunity in children genetically at-risk of type 1 diabetes. Diabetes. 2014 Feb 21

Pepper RJ, Hamour S, Chavele KM, Todd SK, Rasmussen N, Flint S, Lyons PA, Smith KGC, Pusey CD, Cook HT, Salama AD. (2013) Leukocyte and serum S100A8/S100A9 expression reflects disease activity in ANCA-associated vasculitis and glomerulonephritis. Kidney International, 2013;83:1150-8.

Flint, S. M., Walker, R. G., Hogan, C., Haeusler, M. N., Robertson, A., Francis, D. M. A., et al. (2011). Successful ABO-incompatible kidney transplantation with antibody removal and standard immunosuppression. American Journal of Transplantation, 11(5), 1016–1024. doi:10.1111/j.1600-6143.2011.03464.x