Research
Our research utilizes high-throughput genome sequencing to investigate C. difficile populations and intestinal microbial communities that are associated with health and disease, and murine infection models to identify the host genetic factors that are linked to disease susceptibility. Healthcare-associated pathogens are a major focus of the research programme.
Publications
Pham TA, Lawley TD. Emerging insights on intestinal dysbiosis during bacterial infections. Curr Opin Microbiol. 2014 Feb;17C:67-74
Clare S, John V, Walker AW, Hill JL, Abreu-Goodger C, Hale C, Goulding D, Lawley TD, Mastroeni P, Frankel G, Enright AJ, Vigorito E, Dougan G. Enhanced susceptibility to Citrobacter rodentium infection in microRNA-155-deficient mice. Infect Immun. 2013 Mar;81(3):723-32.
He M, Miyajima F, Roberts P, Ellison L, Pickard DJ, Martin MJ, Connor TR, Harris SR, Fairley D, Bamford KB, D'Arc S, Brazier J, Brown D, Coia JE, Douce G,Gerding D, Kim HJ, Koh TH, Kato H, Senoh M, Louie T, Michell S, Butt E, Peacock SJ, Brown NM, Riley T, Songer G, Wilcox M, Pirmohamed M, Kuijper E,Hawkey P, Wren BW, Dougan G, Parkhill J and Lawley TD Emergence and global spread of epidemic healthcare-associated Clostridium difficile. Nature genetics 2013;45;1;109-13
Lawley TD and Walker AW Intestinal colonization resistance.Immunology 2013;138;1;1-11
Lawley TD, Clare S, Walker AW, Stares MD, Connor TR, Raisen C, Goulding D, Rad R, Schreiber F, Brandt C, Deakin LJ, Pickard DJ, Duncan SH, Flint HJ,Clark TG, Parkhill J and Dougan G Targeted restoration of the intestinal microbiota with a simple, defined bacteriotherapy resolves relapsing Clostridium difficile disease in mice. PLoS pathogens 2012;8;10;e1002995
Lawley TD, Clare S, Walker AW, Goulding D, Stabler RA, Croucher N, Mastroeni P, Scott P, Raisen C, Mottram L, Fairweather NF, Wren BW, Parkhill J, Dougan G. Antibiotic treatment of clostridium difficile carrier mice triggers a supershedder state, spore-mediated transmission, and severe disease in immunocompromised hosts. Infect Immun. 2009 Sep;77(9):3661-9.
