Reader in Infection and Immunity
Bacterial immunology
Pathogenesis
Vaccines
Immune-deficiency
Pietro Mastroeni is accepting applications for PhD students.
Pietro Mastroeni is available for consultancy.
Departments
Research Interests
My research focuses on pathogenesis and immunity to bacterial infections, vaccine development and the interactions between the immune system and antibiotic treatment.
My group has developed new multidisciplinary biological and mathematical approaches that allow in-depth analysis of the complex and multifaceted interactions between bacterial virulence genes, host cell receptors, antimicrobial functions and immune-evasion mechanisms.
Keywordsphagocytosis ; B cells ; microarrays ; microscopy ; confocal microscopy ; interleukin ; cytokines ; molecular biology ; B cell receptor (BCR) ; pathogenesis ; regulation ; inflammation ; monocytes ; proteomics ; immunity ; enzyme assays ; immunohistochemistry ; Fc receptors ; macrophages ; apoptosis ; activation ; immunoglobulins ; T cells ; human studies ; antibody responses ; animal models ; helper T cells ; cell culture ; fluorescence microscopy ; FACS |
Topics
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Collaborators
Key Publications
Selected recent publications
Within-host spatiotemporal dynamics of systemic Salmonella infection during and after antimicrobial treatment. O. Rossi, R. Dybowski, D. Maskell, A. Grant, O. Restif, P. Mastroeni. J. Antimicrob. Chemother., https://doi.org/10.1093/jac/dkx294.
Transcriptome and proteome analysis of Salmonella enterica Serovar Typhimurium Infection of wild type C57BL/6 and immunodeficient gp91-/-phoxmice. O. Oshota, M. Fookes, F. Schreiber, R.Chaudhuri, L. Yu, F. Morgan, S. Clare, J. Choudhary, N. Thomson, D. Maskell, Pietro Mastroeni, A. Grant. Plos One., 2017 Aug 10;12(8):e0181365. doi: 10.1371/journal.pone.0181365
Genes required for the fitness of Salmonella enterica serovar Typhimurium during infection of immunodeficient gp91-/-phox mice". A. Grant, O. Oshota, R. Chaudhuri, M. Mayho, S. Peters, S. Clare, D. Maskell, Pietro Mastroeni. Infect. Immun. 2016; 84: 989-997.
Design of glycoconjugate vaccines against invasive African S. Typhimurium. S. Rondini, F. Micoli, L. Lanzilao, M. Gavini, Pietro Mastroeni, C. Brandt, A. Saul, C. MacLennan. Infect. Immun. 2015; 83:996-1007.
Monoclonal antibodies of diverse isotype induced by an O-antigen glycoconjugate vaccine mediate in vitro and in vivo killing of African invasive nontyphoidal Salmonella. Y.S. Goh,S. Clare, F. Micoli, A. Saul, Pietro Mastroeni,Calman A. MacLennan. Infect. Immun. 2015; 83:3722-3731.
TARM1 is a novel leukocyte receptor complex-encoded ITAM receptor that costimulates proinflammatory cytokine secretion by macrophages and neutrophils. V. Radjabova, Pietro Mastroeni, K. Skjodt, P. Zaccone, B. de Bono, J Goodall, E. Chilvers, J. Juss, D. Jones, J. Trowsdale, A. Barrow. J. Immunol.2015; 195:3149-3159.
The effects of vaccination and immunity on bacterial infection dynamics in vivo. C. Coward, O. Restif, R. Dybowski, A. Grant, D. Maskell, Pietro Mastroeni. PLoS Pathog. 2014; 10(9):e1004359.
Recent reviews
Immunology, epidemiology and mathematical modelling towards a better understanding of invasive non-typhoidal Salmonella disease and rational vaccination approaches. Pietro Mastroeni, O. Rossi. Expert Reviews of Vaccines, 2016, DOI:10.1080/14760584.2016.1189330.
Immunological basis of increased susceptibility to invasive nontyphoidal Salmonella infection in children with malaria and anaemia. T. Nyirenda, W. Mandala, M. Gordon, Pietro Mastroeni. Microbes and Infection, in press
