skip to primary navigationskip to content
 

Professor Klaus Okkenhaug

Professor Klaus Okkenhaug

Professor of Immunology

Areas of Interest:

-Immunity

-Infection

-Cancer

-Immunodeficiency

Klaus Okkenhaug is accepting applications for PhD students.

Klaus Okkenhaug is available for consultancy.


Office Phone: 01223 333726

Departments

Babraham Institute:
Professor

Keywords

CD28 ; B cell receptor (BCR) ; B cells ; PI3K ; cell surface molecules ; cell processes ; activation ; signal transduction ; T cells ; cell type ; CD4 ; helper T cells ; CD8+ ; CD4+ ; CTL ; FACS ; signalling ; regulatory T cells ; T cell receptor (TCR) ; CD8 T cells

Topics

  • autoimmunity
  • cancer
  • Primary Immunodeficiency
  • immunotherapy
  • infectious diseases

Key Publications

Ali K, Soond DR, Piñeiro R, Hagemann T, Pearce W, Lim EL, Bouabe H, Scudamore CL, Hancox T, Maecker H, Friedman L, Turner M, Okkenhaug K, Vanhaesebroeck B. Inactivation of PI(3)K p110δ breaks regulatory T-cell-mediated immune tolerance to cancer.
Nature. 2014 Jun 11. doi: 10.1038/nature13444.

Angulo I, Vadas O, Garçon F, Banham-Hall E, Plagnol V, Leahy TR, Baxendale H, Coulter T, Curtis J, Wu C, Blake-Palmer K, Perisic O, Smyth D, Maes M, Fiddler C, Juss J, Cilliers D, Markelj G, Chandra A, Farmer G, Kielkowska A, Clark J, Kracker S, Debré M, Picard C, Pellier I, Jabado N, Morris JA, Barcenas-Morales G, Fischer A, Stephens L, Hawkins P, Barrett JC, Abinun M, Clatworthy M, Durandy A, Doffinger R, Chilvers E, Cant AJ, Kumararatne D, Okkenhaug K, Williams RL, Condliffe A, Nejentsev S. Phosphoinositide 3-Kinase δ Gene Mutation Predisposes to Respiratory Infection and Airway Damage.       Science. 2013  342(6160):866-71.

Okkenhaug K. Signaling by the phosphoinositide 3-kinase family in immune cells. Annu Rev Immunol. 2013;31:675-704.

Banham-Hall E, Clatworthy MR, Okkenhaug K. The Therapeutic Potential for PI3K Inhibitors in Autoimmune Rheumatic Diseases. Open Rheumatol J. 2012;6:245-58

Soond DR, F. Garcon DT, Patton J, Rolf M, Turner C, Scudamore OA, Garden, and K, Okkenhaug. Pten Loss in CD4 T Cells Enhances Their Helper Function but Does Not Lead to Autoimmunity or Lymphoma, J Immunol, 2012. 188.

The PI3K p110δ regulates expression of CD38 on regulatory T cells. Patton DT, Wilson MD, Rowan WC, Soond DR, Okkenhaug K. PLoS One. 2011 Mar 1;6(3)

Ramadani F, D J, Bolland F, Garcon JL, Emery B, Vanhaesebroeck AE, Corcoran, and K, Okkenhaug, The PI3K isoforms p110alpha and p110delta are essential for pre-B cell receptor signaling and B cell development, Sci Signal, 2010. 3(134): ra60.

Soond DR, E. Bjorgo K, Moltu VQ, Dale DT, Patton KM, Torgersen F, Galleway B, Twomey J, Clark JS, Gaston K, Tasken P, Bunyard, and K, Okkenhaug, PI3K p110delta regulates T-cell cytokine production during primary and secondary immune responses in mice and humans, Blood, 2010. 115(11): 2203–13

Garcon F, Patton DT, Emery JL, Hirsch E, Rottapel R, Sasaki T, Okkenhaug K (2008), CD28 provides T-cell costimulation and enhances PI3K activity at the immune synapse independently of its capacity to interact with the p85/p110 heterodimer, Blood 111 1464–1471

PIP3 (green) and PKC (blue) visualised at the synapse formed by a B cell and T cell.