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Professor Klaus Okkenhaug

Professor Klaus Okkenhaug

Professor of Immunology

Areas of Interest:

-Immunity

-Infection

-Cancer

-Immunodeficiency

Klaus Okkenhaug is accepting applications for PhD students.

Klaus Okkenhaug is available for consultancy.


Office Phone: 01223 333726

Departments

Babraham Institute:
Professor

Keywords

CD28 ; B cell receptor (BCR) ; B cells ; PI3K ; cell surface molecules ; cell processes ; activation ; signal transduction ; T cells ; cell type ; CD4 ; helper T cells ; CD8+ ; CD4+ ; CTL ; FACS ; signalling ; regulatory T cells ; T cell receptor (TCR) ; CD8 T cells

Topics

  • autoimmunity
  • cancer
  • Primary Immunodeficiency
  • immunotherapy
  • infectious diseases

Key Publications

PI3Kδ hyper-activation promotes development of B cells that exacerbate Streptococcus pneumoniae infection in an antibody-independent manner. Stark AK, Chandra A, Chakraborty K, Alam R, Carbonaro V, Clark J, Sriskantharajah S, Bradley G, Richter AG, Banham-Hall E, Clatworthy MR, Nejentsev S, Hamblin JN, Hessel EM, Condliffe AM, Okkenhaug K. Nat Commun. 2018 Aug 9;9(1):3174. DOI: 10.1038/s41467-018-05674-8

 

Phosphoinositide 3-kinase δ inhibition promotes antitumor responses but antagonizes checkpoint inhibitors. Lim EL, Cugliandolo FM, Rosner DR, Gyori D, Roychoudhuri R, Okkenhaug K. JCI Insight. 2018 Jun 7;3(11). pii: 120626. doi: 10.1172/jci.insight.120626. DOI: 10.1172/jci.insight.120626

 

PI3Kδ promotes CD4(+) T-cell interactions with antigen-presenting cells by increasing LFA-1 binding to ICAM-1. Garçon F and Okkenhaug K. Immunol Cell Biol. 2016 May;94(5):486-95. doi: 10.1038/icb.2016.1. PMCID: PMC4829101 DOI: 10.1038/icb.2016.1

 

PI3Kδ Regulates the Magnitude of CD8+ T Cell Responses after Challenge with Listeria monocytogenes. Pearce VQ, Bouabe H, MacQueen AR, Carbonaro V, Okkenhaug K. J Immunol. 2015 Oct 1;195(7):3206-17. PMCID: PMC4574522 DOI: 10.4049/jimmunol.1501227

 

Inactivation of PI(3)K p110δ breaks regulatory T-cell-mediated immune tolerance to cancer. Ali K, Soond DR, Pineiro R, Hagemann T, Pearce W, Lim EL, Bouabe H, Scudamore CL, Hancox T, Maecker H, Friedman L, Turner M, Okkenhaug K, Vanhaesebroeck B. Nature. 2014 Jun 19;510(7505):407-411. PMCID: PMC4501086 DOI: 10.1038/nature13444

 

Phosphoinositide 3-kinase δ gene mutation predisposes to respiratory infection and airway damage. Angulo I, Vadas O, Garçon F, Banham-Hall E, Plagnol V, Leahy TR, Baxendale H, Coulter T, Curtis J, Wu C, Blake-Palmer K, Perisic O, Smyth D, Maes M, Fiddler C, Juss J, Cilliers D, Markelj G, Chandra A, Farmer G, Kielkowska A, Clark J, Kracker S, Debré M, Picard C, Pellier I, Jabado N, Morris JA, Barcenas-Morales G, Fischer A, Stephens L, Hawkins P, Barrett JC, Abinun M, Clatworthy M, Durandy A, Doffinger R, Chilvers ER, Cant AJ, Kumararatne D, Okkenhaug K, Williams RL, Condliffe A, Nejentsev S. Science. 2013 Nov 15;342(6160):866-71. PMCID: PMC3930011 DOI: 10.1126/science.1243292

PIP3 (green) and PKC (blue) visualised at the synapse formed by a B cell and T cell.