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Cambridge Immunology Network



There are striking structural similarities between sites of cilia formation and the immunological synapse (IS) of cytotoxic T lymphocytes (CTL) which prompted us to propose that the IS might be a "frustrated cilium". In my research I try to find out whether these similarities go beyond the morphological.


Key publications: 

de la Roche M, Ritter AT, Angus KL, Dinsmore C, Earnshaw CH, Reiter JF, Griffiths GM. Hedgehog signaling controls T cell killing at the immunological synapse. Science. 2013 Dec 6;342(6163):1247-50.

James E. D. Thaventhiran, Anja Hoffmann, Lukasz Magiera, Maike de la Roche, Holger Lingel, Monika Brunner-Weinzierl, Douglas T. Fearon. Activation of the Hippo pathway by CTLA-4 regulates the expression of Blimp-1 in the CD8+ T cell Proc Natl Acad Sci U S A. 2012 August 14; 109(33)

Andy Tsun, Ihjaaz Qureshi, Jane C. Stinchcombe, Misty R. Jenkins, Maike de la Roche, Joanna Kleczkowska, Rose Zamoyska, Gillian M. Griffiths Centrosome docking at the immunological synapse is controlled by Lck signaling J Cell Biol. 2011 February 21; 192(4): 663–674.

Heffner MFearon DT. Loss of T cell receptor-induced Bmi-1 in the KLRG1(+) senescent CD8(+) T lymphocyte. Proc Natl Acad Sci U S A. 2007 Aug 14;104(33):13414-9.

Dr Maike  de la Roche
Not available for consultancy


Person keywords: 
T lymphocyte
cytotoxic T cells (CTL)
T cell receptor (TCR)
immunological synapse