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Cambridge Immunology Network



Maike completed her veterinary degree in Germany before pursuing her interest in immunology at the NIH, USA. In 2004 Maike moved to Cambridge, UK, to carry out her Doctoral work in the laboratory of Prof. D. T. Fearon at the MRC Laboratory of Molecular Biology and her Postdoctoral work with Prof. G.M. Griffiths at the Cambridge Institute for Medical Research. Maike is a recipient of a Sir Henry Dale Fellowship and  started her own lab in 2016.


Dr Maike de la Roche is a group leader at the Cancer Research UK Cambridge Institute, where her lab works to understand the roles of the Hedgehog signalling pathway in immune cells, focusing on its roles in effector and memory cell differentiation, maintenance and function during infection and tumor challenge


Key publications: 

Hung-Chang Chen1, Nils Eling1,2,*, Celia Pilar Martinez-Jimenez1,3,4,*, Louise McNeill O’Brien1, Valentina Carbonaro1, John C. Marioni1,2,3, Duncan T. Odom1,3,5, and Maike de la Roche1,§, IL-7-dependent compositional changes of the gd T cell pool in lymph nodes during ageing lead to an unbalanced anti-tumour response, EMBO Reports, 2019


de la Roche M* , Asano Y, Griffiths GM*, Origins of the cytolytic synapse. Nature Reviews Immunology, 2016 Jul;16(7):421-32 *corresponding authors


de la Roche M, Ritter AT, Angus KL, Dinsmore C, Earnshaw CH, Reiter JF, Griffiths GM (2013) Hedgehog signaling controls T cell killing at the immunological synapse.

Science, 2013 Dec 6;342(6163):1247-50

(recommended as “outstanding” by Faculty of 1000)


Maike Heffner and Douglas T. Fearon (2007). Loss of T cell receptor-induced Bmi-1 in the KLRG1+ senescent CD8+ T lymphocyte. Proc Natl Acad Sci USA, 104(33):13414-9


Other publications: 

Nadine Nelson, Marta Lopez-Pelaez, Asis Palazon, Edmund Poon, Maike De La Roche, Simon Barry, Viia Valge-Archer, Robert W. Wilkinson, Simon J. Dovedi & Paul D. Smith, A cell-engineered system to assess tumor cell sensitivity to CD8+ T cell mediated cytotoxicity, OncoImmunology, 2019,


IIca FT, Neerincx A, Wills MR, de la Roche M, Boyle LH, Utilizing TAPBPR to promote exogenous peptide loading onto cell surface MHC I molecules Proc Natl Acad Sci USA, 2018, Oct 115 (40): E9353-E9361


Jenks AD, Vyse S, Wong JP, Kostaras E, Keller D, Burgoyne T, Shoemark A, Tsalikis A, de la Roche M, Michaelis M, Cinatl J, Jr, Huang PH, Tanos BE, Primary Cilia Mediate Diverse Kinase Inhibitor Resistance Mechanisms in Cancer Cell Reports, 2018 June, 23 3042-3055


Cassidy L, Young ARJ, Perez-Mancera P, Nimmervoll B, Jaulim A, Chen H-C, McIntyre D, Brais R, Ricketts T, Pacey S, de la Roche M, Gilbertson R, Rubinsztein D, Narita M, A Novel Atg5-shRNA Mouse Model Enables Temporal Control of Autophagy in vivo.  Autophagy, 2018 Jul 12: 1-11


C.P. Martinez-Jimenez, N. Eling, H.C. Chen, C.A. Vallejos, A.A. Kolodziejczyk, F. Connor, L. Stojic, T.F. Rayner, M.J. Stubbington, S.A. Teichmann, M. de la Roche, J.C. Marioni and D.T. Odom, Aging increases cell-to-cell transcriptional variability upon immune stimulation Science, 2017, April 355(6332):1433-36, 1


James E.D. Thaventhiran, Anja Hoffmann, Lukasz Magiera, Maike de la Roche, Holger Lingel, Monika Brunner-Weinzierl, and Douglas T. Fearon (2012) Activation of the Hippo pathway by CTLA-4 regulates the expression of Blimp-1 in the CD8+ T cell.  Proc Natl Acad Sci USA


Tsun A, Qureshi I, Stinchcombe JC, Jenkins MR, de la Roche M, Kleczkowska J, Zamoyska R, Griffiths GM (2011) Centrosome docking at the immunological synapse is controlled by Lck signaling. J Cell Biol. 2011 Feb 21;192(4): 663-74