Dr Rupert Beale

I am interested in defining mechanisms related to autophagy that effect cell autonomous immune responses to influenza and other viruses.

Research

I am interested in cell autonomous immunity, innate immune responses to exogenous nucleic acids and viruses.

Publications

Key publications:

Katherine Fletcher†, Rachel Ulferts†, Elise Jacquin, TalithaVeith, Noor Gammoh, Julia M Arasteh, Ulrike Mayer, Simon R Carding, Thomas Wileman, Rupert Beale*, Oliver Florey* The WD40 domain of ATG16L1 is required for its non‐canonical role in lipidation of LC3 at single membranes The EMBO Journal (2018) e97840

Rupert Beale, Helen Wise, Amanda Stuart,Benjamin J. Ravenhill,Paul Digard, Felix Randow 2014 A LC3-Interacting Motif in the Influenza A Virus M2 Protein Is Required to Subvert Autophagy and Maintain Virion Stability Cell Host & Microbe, Volume 15, Issue 2, 239-247, 12

Other publications:

Langlois MA, Beale RC, Conticello SG, Neuberger MS. Mutational comparison of the single-domained APOBEC3C and double-domained APOBEC3F/G anti-retroviral cytidine deaminases provides insight into their DNA target site specificities. Nucleic Acids Res. 2005 Apr 4;33(6):1913-23.

Neuberger MS, Di Noia JM, Beale RC, Williams GT, Yang Z, Rada C. Somatic hypermutation at A.T pairs: polymerase error versus dUTP incorporation. Nat Rev Immunol. 2005 Feb;5(2):171-8.

Beale RC, Petersen-Mahrt SK, Watt IN, Harris RS, Rada C, Neuberger MS. Comparison of the differential context-dependence of DNA deamination by APOBEC enzymes: correlation with mutation spectra in vivo. J Mol Biol. 2004 Mar 26;337(3):585-96.

Subject:

autoimmunity

viruses