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Dr Rupert Beale

MRC Clinician Scientist Fellow

I am interested in defining mechanisms related to autophagy that effect cell autonomous immune responses to influenza and other viruses.

Rupert Beale is accepting applications for PhD students.

Rupert Beale is available for consultancy.

Research Interests

I am interested in cell autonomous immunity, innate immune responses to exogenous nucleic acids and viruses.


autoimmunity ; signal transduction ; Autophagy ; Autophagy, Endocytosis ; signalling ; RNA viruses ; DNA viruses


  • influenza
  • transplantation


  • Imaging Flow Cytometry,
  • Flow Cytometry,

Key Publications

Katherine Fletcher†Rachel Ulferts†Elise JacquinTalithaVeithNoor GammohJulia M ArastehUlrike MayerSimon R CardingThomas WilemanRupert Beale*Oliver FloreyThe WD40 domain of ATG16L1 is required for its non‐canonical role in lipidation of LC3 at single membranes The EMBO Journal (2018) e97840

Rupert Beale, Helen Wise, Amanda Stuart,Benjamin J. Ravenhill,Paul Digard, Felix Randow 2014 A LC3-Interacting Motif in the Influenza A Virus M2 Protein Is Required to Subvert Autophagy and Maintain Virion Stability Cell Host & Microbe, Volume 15, Issue 2, 239-247, 12 



Other Publications

Langlois MA, Beale RC, Conticello SG, Neuberger MS. Mutational comparison of the single-domained APOBEC3C and double-domained APOBEC3F/G anti-retroviral cytidine deaminases provides insight into their DNA target site specificities. Nucleic Acids Res. 2005 Apr 4;33(6):1913-23.

Neuberger MS, Di Noia JM, Beale RC, Williams GT, Yang Z, Rada C. Somatic hypermutation at A.T pairs: polymerase error versus dUTP incorporation. Nat Rev Immunol. 2005 Feb;5(2):171-8.


Beale RC, Petersen-Mahrt SK, Watt IN, Harris RS, Rada C, Neuberger MS. Comparison of the differential context-dependence of DNA deamination by APOBEC enzymes: correlation with mutation spectra in vivoJ Mol Biol. 2004 Mar 26;337(3):585-96.