Research
I am interested in the maintenance of B cell immune tolerance and mechanisms leading to its breakdown. My current research focuses on identification of tissue-resident B cells across multiple non-lymphoid organs in both mouse and human and examination of their role in shaping local organ immunity. Therapeutic modulation of tissue-resident B cells may have important clinical implications in conditions such as transplant rejection, autoimmunity and cancer.
Publications
Wallin EF, Jolly EC, Suchánek O, Bradley JA, Espéli M, Jayne DR, Linterman MA, Smith KG. Human T follicular helper and T follicular regulatory cell maintenance is independent of germinal centers. Blood. 2014 Sep 15. pii: blood-2014-07-585976.
Suchanek O, Sadler R, Bateman E, Patel S, Ferry B. Immunophenotyping of putative human B1 B-cells in healthy controls and common variable immunodeficiency (CVID) patients. Clin Exp Immunol. 2012; Dec;170(3):333-41.
Suchanek O, Podrazil M, Fischerova B, Bocinska H, Budinsky V, Stejskal D, Spisek R, Bartunkova J, Kolar P. Intensive physical activity increases peripheral blood dendritic cells. Cell Immunol. 2010;266(1):40-5.
