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Cambridge Immunology Network



I am interested in the maintenance of B cell immune tolerance and mechanisms leading to its breakdown. My current research focuses on identification of tissue-resident B cells across multiple non-lymphoid organs in both mouse and human and examination of their role in shaping local organ immunity. Therapeutic modulation of tissue-resident B cells may have important clinical implications in conditions such as transplant rejection, autoimmunity and cancer.  



Key publications: 

Wallin EF, Jolly EC, Suchánek O, Bradley JA, Espéli M, Jayne DR, Linterman MA, Smith KG. Human T follicular helper and T follicular regulatory cell maintenance is independent of germinal centers. Blood. 2014 Sep 15. pii: blood-2014-07-585976. 

Suchanek O, Sadler R, Bateman E, Patel S, Ferry B. Immunophenotyping of putative human B1 B-cells in healthy controls and common variable immunodeficiency (CVID) patients. Clin Exp Immunol. 2012; Dec;170(3):333-41.

Suchanek O, Podrazil M, Fischerova B, Bocinska H, Budinsky V, Stejskal D, Spisek R, Bartunkova J, Kolar P. Intensive physical activity increases peripheral blood dendritic cells. Cell Immunol. 2010;266(1):40-5.

Dr  Ondrej   Suchanek
Not available for consultancy


Person keywords: 
B cells
single cell mRNA sequencing
Autoimmune diseases
immune tolerance
B cell lineage and repertoire development
plasma cells