Dr Paul Lyons

Research

For a number of years I have been interested in applying high-throughput genomic approaches to the study of autoimmune disease. Most recently I have been involved in the establishment of the Cambridge Hinxton Centre for Translational Research in Autoimmune Disease. This is a collaboration between clinicians, basic scientists and bioinformaticians that aims to apply expression profiling to the clinical management of autoimmune diseases such as systemic lupus erythematosus and small vessel vasculitis. We have developed and optimised a cell selection strategy that enables us to expression profile purified leukocyte subsets isolated from patients with active disease pre- and post-treatment. This should enable the development of novel biomarkers that can be used to stratify patients at presentation, select appropriate treatment protocols, monitor response and predict relapse. In addition, it may also provide insight into the molecular pathogenesis of disease.

Publications

Key publications:

Lee JC, EspéliM, AndersonCA, Linterman MA, PocockJM, Williams NJ, Roberts R, Viatte S, F uB, PeshuN, Tran TH, Nguyen HP, WesleyE, EdwardsC, AhmadT, MansfieldJC, Gearry R, Dunstan S, Williams TS, BartonA, VinuesaCG, UK IBD Genetics Consortium, ParkesM, LyonsPA, SmithKGC. Human SNP links differential outcomes in inflammatory and infectious disease to a FOXO3-regulated pathway. Cell 2013: 155(1):57-69.

Lyons PA, Rayner TF, Trivedi S, Holle JU, Watts RA, Jayne DR, Baslund B, Brenchley P, Bruchfeld A, Chaudhry AN, Cohen Tervaert JW, Deloukas P, Feighery C, Gross WL, Guillevin L, Gunnarsson I, Harper L, Hrušková Z, Little MA, Martorana D, Neumann T, Ohlsson S, Padmanabhan S, Pusey CD, Salama AD, Sanders JS, Savage CO, Segelmark M, Stegeman CA, Tesař V, Vaglio A, Wieczorek S, Wilde B, Zwerina J, Rees AJ, Clayton DG, Smith KG. Genetically distinct subsets within ANCA-associated vasculitis. N Engl J Med. 2012 Jul 19;367(3):214-23.

Walker JA, Hall AM, Kotsopoulou E, Espéli M, Nitschke L, Barker RN, Lyons PA, Smith KG. Increased red cell turnover in a line of CD22-deficient mice is caused by Gpi1(c) : A model for hereditary hemolytic anemia. Eur J Immunol. 2012 Aug 29. Epub ahead of print

Lee JC, Lyons PA, McKinney EF, Sowerby JM, Carr EJ, Bredin F, Rickman HM, Ratlamwala H, Hatton A, Rayner TF, Parkes M, Smith KG. Gene expression profiling of CD8+ T cells predicts prognosis in patients with Crohn disease and ulcerative colitis. J Clin Invest. 2011 Oct;121(10):4170-9

Willcocks, LC*, Lyons, PA*, Clatworthy, MR, Robinson, JI, Yang, W, Newland, SA, Plagnol, V, McGovern, NN, Condliffe, AM, Chilvers, ER, Adu, D, Jolly, EC, Watts, R, Lau, YL, Morgan, AW, Nash, G and Smith, KGC , Copy number of FCGR3B, which is associated with systemic lupus erythematosus, correlates with protein expression and immune complex uptake J Exp Med 2008 205(7): 1573–82

Lyons, PA, Koukoulaki, M, Hatton, A, Doggett, K, Woffendin, HB, Chaudhry, AN and Smith, KG , Microarray analysis of human leucocyte subsets: the advantages of positive selection and rapid purification BMC Genomics 2007 8:64

Newland, SA, Macaulay, IC, Floto, AR, de Vet, EC, Ouwehand, WH, Watkins, NA, Lyons, PA* and Campbell, RD*, The novel inhibitory receptor G6B is expressed on the surface of platelets and attenuates platelet function in vitro Blood 2007109(11): 4806–9

Other publications: