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Cambridge Immunology Network

Biomedical Research Centre
3D cell culture


Bone Morphogenic Proteins

Pulmonary Arterial Hypertension



Key publications: 

Wilkinson JM, Waters JP, Morrell N, Upton PD. BMP9 and BMP10 have antiangiogenic effect on human endothelial tube networks in a 3D Collagen and Fibronectin matrix (In progress)

Long L, Ormiston ML, Yang X, Southwood M, Gräf S, Machado RD, Mueller M, Kinzel B, Yung LM, Wilkinson JM, Moore SD, Drake KM, Aldred MA, Yu PB, Upton PD, Morrell NW. Selective enhancement of endothelial BMPR-II with BMP9 reverses pulmonary arterial hypertension. Nat Med. 2015 Jul;21(7):777-85. doi: 10.1038/nm.3877. Epub 2015 Jun 15.

PD Upton, JM Wilkinson, KA Wiggins, NW MorrellS35 Bmp9 And Bmp10 Mediate Connexin Expression In Endothelial Cells: Implications For PAH And HHT Thorax 2014;69:A20-A21 doi:10.1136/thoraxjnl-2014-206260.41

Wilkinson JM, Davidson RK, Swingler TE, Jones ER, Corps AN, Johnston P, Riley GP, Chojnowski AJ, Clark IM MMP-14 and MMP-2 are key metalloproteases in Dupuytren's disease fibroblast-mediated contraction. Biochim Biophys Acta. 2012 Jun;1822(6):897-905. doi: 10.1016/j.bbadis.2012.02.001. Epub 2012 Feb 9.